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Grants starting October 2002

Projects funded from 1 October 2002

Location: Ben-Gurion University of the Negev, Israel
Project Title: IL-1 as a mediator of the angiogenic switch in tumours
Funds Awarded: £92,403

Location: VIB - Ghent University, Belgium
Project Title: Analysis of the Smad-interacting protein-1 (SIP1) as an invasion inducer in carcinomas
Funds Awarded: £106,117

Location: Imperial College of Science Technology & Medicine
Project Title: Functional characterisation of novel androgen receptor-interacting proteins.
Funds Awarded: £75,850

Location: Institute of Child Health
Project Title: Mechanisms mediating over-expression of the Brn-3b transcription factor in breast tumour
Funds Awarded: £112,560

Location: Salford University, England
Project Title: DT-Diaphorase Activated Anti-vasculature Agents
Funds Awarded: £68,415

Location: University of East Anglia, England
Project Title: Cross regulation of BCR-ABL and TGFB signalling pathways in chronic myeloid leukaemia
Funds Awarded: £64,050

Location: Marie Curie Research Institute
Project Title: Characterization of swil and swi3 mediated replication-termination, pausing and genome stability in fission yeast.
Funds Awarded: £168,366

Location: University of Sheffield, England
Project Title: Synergistic activation of apoptosis for cancer therapy
Funds Awarded: £114,062

Location: University College London, England
Project Title: Molecular mechanisms regulating sorting of ErbB receptors and the role of the endosome in regulating mitogenic signalling
Funds Awarded: £156,210

Location: University of Leicester, England
Project Title: Comparison of Pharmacokinetic and Pharmacodynamic Properties of Curcumin in Min Mice and Patients with Surgically Resectable Colorectal Cancer.
Funds Awarded: £107,349

Location: Marie Curie Research Institute
Project Title: Understanding transcription and signalling in melanoma as an approach to therapy
Funds Awarded: £122,934

Location: Campus de Cantoblanco
Project Title: Analysis of the tumour regulatory effect of APRIL, a TNF family member.
Funds Awarded: £131,544

Location: Erasmus University Rotterdam, The Netherlands
Project Title: Transcription factor GATA-3: a key regulator of proliferation and differentiation in T lymphocyte development
Funds Awarded: £128,300

Location: University of Dundee, Scotland
Project Title: Molecular Mechanisms of Wnt Protein Function and Inhibition of Wnt Protein Function in Development and Oncogenesis
Funds Awarded: £42,504

Location: University of Surrey, England
Project Title: Pharmacokinetics of the chemopreventive phytochemical sulphoraphane
Funds Awarded: £126,454

Location: Skirball Institute for Biomedical Research
Project Title: The role of tyrosine phosphatase SHP-1 in tumour suppression and T cell antigen receptor signaling
Funds Awarded: £91,271

Location: Imperial Cancer Research Fund
Project Title: The role of photoactivation of DNA 6-thioguanine in skin cancer in organ transplant recipients
Funds Awarded: £120,277

Location: University of Glasgow, Scotland
Project Title: A novel transcription co-activator complex for the p53 tumour suppressor protein
Funds Awarded: £67,050

Location: University of Birmingham, England
Project Title: Genetic and Functional analysis of RASSF1A tumour suppressor gene at 3p21.3
Funds Awarded: £128,561

Location: Ludwig Institute for Cancer Research
Project Title: Investigating the tumour suppression function of ASPP2 and its interaction with p53 in vivo
Funds Awarded: £153,524

Location: University of Edinburgh, Scotland
Project Title: An investigation into the role of APC in medulloblastoma
Funds Awarded: £116,990

Location: Texas A&M University System Health Science Centre, United States of America
Project Title: Functional Interactions of PIASy with STAT1 and an E2 Ubiquitin Conjugase in Cellular Transformation and Apoptosis.
Funds Awarded: £123,847

Location: National Cancer Institute
Project Title: Understanding Bmi-1 mediated Epigenetic Mechanisms in Tumourigenesis
Funds Awarded: £132,743

Location: European Molecular Biology Laboratory
Project Title: Characterization of RINGO, a novel family of proteins that regulate the activity of cyclin-dependent kinases (Cdks)
Funds Awarded: £113,946

Location: Medical Research Council
Project Title: A novel approach to selecting and maturing antibodies/ligands for directed cell targeting
Funds Awarded: £127,547

Location: Medical Research Council
Project Title: NMR Structure Determination of the DNA-Binding Domain of DNA ligase III and its Complex with Nicked DNA
Funds Awarded: £34,526

Location: University of Warwick, England
Project Title: Mouse models for investigating the oncogenic potential of c-Myc
Funds Awarded: £146,751

Location: University College London, England
Project Title: Regulation of dual-specificity phosphatases by cell stress
Funds Awarded: £73,050

Location: Gray Cancer Institute
Project Title: Imaging protein-protein kinetics in the activation pathways of NFkB and PKC: Modification by cancer treatment
Funds Awarded: £36,780

Location: University of Manchester, England
Project Title: Modulation of the Wilms' tumour suppressor protein function in vivo by synthetic peptides
Funds Awarded: £111,745

Location: University of Bern, Switzerland
Project Title: Molecular mechanisms of HIPK2 function in acute promyelocytic leukemia
Funds Awarded: £77,615

Location: Medical University of Ulm, Germany
Project Title: Role of the protein kinase D (PKD) family kinases PKD/protein kinase Cu (PKCu) & protein kinase D2 (PKD2) in gastrin-stimulated proliferation, apoptosis & invasion of human colon cancer cells
Funds Awarded: £80,669

Location: University of Edinburgh, Scotland
Project Title: Studies of the anti-tumour mechanisms of NSAIDs in colorectal cancer
Funds Awarded: £105,098

Location: University of Manchester, England
Project Title: Do truncating mutations in the adenomatous polyposis coli gene initiate chromosome instability in colorectal cancer?
Funds Awarded: £134,904

Location: Centre National de la Recherche Scientifique
Project Title: The study of Integrin-linked Kinase in Vascular Endothelial Cells: Role in Tumour Angiogenesis
Funds Awarded: £107,055

Location: University Hospital Geneva, Switzerland
Project Title: Immunotherapy for brain tumours: a critical balance between immunoprotection and immunopathology
Funds Awarded: £137,045

Location: Pasteur Institute
Project Title: Role of AP-1 in regulating the choice between cell survival and apoptosis
Funds Awarded: £137,804

By funding only the best science, we ensure that we have the highest chance of making significant progress.  Applications for funding are peer reviewed by our Scientific Advisory Committee and many are also sent to two experts in the field for external review.

 

 

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