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Grants starting April 2001

Projects funded from April 2001

Location: University of Dundee, Scotland
Project Title: Mechanism of activation and physiological function of LKB1; the protein kinase mutated in Peutz-Jeghers cancer syndrome
Funds Awarded: £112,003

Location: Imperial College of Science, Technology & Medicine
Project Title: Gene Inactivation by Chromatin Engineering: a novel approach to inactivating androgen-regulated Genes in prostate cancer
Funds Awarded: £139,649

Location: Imperial Cancer Research Fund
Project Title: The Role of Calcineurin in Oncogenesis
Funds Awarded: £125,097

Location: University of Southampton, England
Project Title: The mechanisms of p53-independent regulation of mdm-2 gene expression and their role in breast tumour progression
Funds Awarded: £116,672

Location: The Netherlands Cancer Institute, The Netherlands
Project Title: Tumourigenesis in TIAM1 Mutant Mice
Funds Awarded: £132,965

Location: Instituto de Investigaciones Biomedicas
Project Title: Regulation of the activation of the Ras/MAP kinase pathway by Ras-GRF: role of the Dbl-homology (DH) domain and Cdc42.
Funds Awarded: £75,190

Location: European Institute of Oncology
Project Title: Function(s) and biological role(s) of RN-tre a novel Rab-specific GAP protein
Funds Awarded: £120,000

Location: Medical Research Council
Project Title: The role of Poly(A)-binding protein in translational control: Understanding its contribution to cancer
Funds Awarded: £140,219

Location: The University of Liverpool, England
Project Title: Cancer Apoptosis by Specific Inhibition of Hsp90
Funds Awarded: £61,255

Location: International Agency for Research on Cancer
Project Title: Role of the Ataxia Telangiectasia Gene (ATM) in Prostate Cancer
Funds Awarded: £22,650

Location: Biomedical Research Centre
Project Title: Functional significance of the ARE gene battery in the action of cancer chemopreventive blocking agents
Funds Awarded: £134,785

Location: Keele University, England
Project Title: Isolation and characterisation of BALF1, a novel homologue of the Bcl-2 oncogene, from Epstein Barr virus and primate virus analogues
Funds Awarded: £51,920

Location: Imperial College of Science, Technology & Medicine
Project Title: Regulation of the hyaluronan receptor, CD44, by its cytoplasmic domain: Implications for tumour progression and metastasis
Funds Awarded: £184,593

Location: National Institute for Medical Research
Project Title: Characterisation of a new branch of the spindle checkpoint involved in coordination of late mitotic events
Funds Awarded: £117,059

Location: University of Oxford, England
Project Title: Chromatin binding of checkpoint proteins
Funds Awarded: £111,298

Location: Technion - Israel Institute of Technology, Israel
Project Title: Analysis of the mechanisms underlying E40rf4-induced apoptosis
Funds Awarded: £108,634

Location: University College London, England
Project Title: Role of the POU family transcription factor Brn-3a in cervical cancer
Funds Awarded: £128,994

Location: University of Dundee, Scotland
Project Title: Identification and functional analysis of phosphorylation sites within the N-terminal domain of MDM2
Funds Awarded: £115,425

Location: University of Exeter, England
Project Title: Inhibition of angiogenesis
Funds Awarded: £50,465

Location: University of Bristol, England
Project Title: The Roles of the Insulin-like growth factor binding proteins in the preferential metastasis of breast cancer cells to bone
Funds Awarded: £114,048

Location: Forschunszentrum Karlsruhe, Germany
Project Title: The hyaluronan receptor CD44 and the tumor suppressor Merlin together control contact inhibition
Funds Awarded: £138,000

Location: Bar-Ilan University, Israel
Project Title: Functional Aspects of the major KSVH/HHV8 Latency-Associated Nuclear Antigen
Funds Awarded: £100,500

Location: University of Queensland, Australia
Project Title: Characterisation of a TGF Beta1-independent but SMAD7-dependent pathway regulating squamous differentiation
Funds Awarded: £85,938

Location: Medical Research Council
Project Title: A screen for genes encoding nuclear and chromosomal proteins in mammalian cells
Funds Awarded: £121,804

Location: The Babraham Institute
Project Title: Defining the role of the RhoG GTPase in differentiation, proliferation and apoptosis
Funds Awarded: £125,008

Location: University of Dundee, Scotland
Project Title: PCNA and its interacting proteins: their role in co-ordinating DNA replication, repair and modification
Funds Awarded: £137,970

Location: Cancer Research Campaign
Project Title: Synthesis of novel indoles as oxidatively-activated substrates for antibody-directed enzyme-prodrug therapy
Funds Awarded: £36,171

Location: Universite Claude Bernard Lyon1, France
Project Title: Functional study of Multiple Endocrine Neoplasia-Type 1 gene (MEN1): generation and characterisation of MEN1 mouse models
Funds Awarded: £48,000

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