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Grants starting October 2006

Projects funded from October 2006

Location: University College London, England
Project Title: Regulation of Rho signalling and epithlial proliferation by GEF-H1/Lfc
Funds Awarded: £147,568

Location: University of Nottingham, England
Project Title: Role of MOZ and MOZ-TIF2 in the pathogenesis of Acute Myeloid Leukemia (AML)
Funds Awarded: £152,504

Location: Netherlands Cancer Institute, The Netherlands
Project Title: Cytoskeletal regulation of cell-cell adhesion in oncogenic transformation
Funds Awarded: £155,320

Location: University of London, England
Project Title: Targeting telomerase: Design synthesis & evaluation of analogues of the G-quadruplex stabilising natural product-telomestatin
Funds Awarded: £178,788

Location: Beatson Institute for Cancer Research, Scotland
Project Title: Identification of novel FERM domain binding partners and their role in cell motility and invasion
Funds Awarded: £138,388

Location: University of Torino, Italy
Project Title:  Role of the GTPase Rab5 in the maintenance of centrosome cohesion and in spindle assembly
Funds Awarded: £26,500

Location: University College London, England
Project Title: alpha-fetoprotein specific TGF-B producing regulatory T cells; their role in modulation of immune responses and tumour invasiveness
Funds Awarded: £137,131

Location: University of East Anglia, England
Project Title: Novel roles for deubiquitination in the SMAD/TGFbeta signalling pathway
Funds Awarded: £122,787

Location: University of Glasgow, Scotland
Project Title: Role of syntaxin 6 in cytokinesis
Funds Awarded: £74,340

Location: Tel Aviv University, Israel
Project Title: Replication clamp loaders and genetic instability
Funds Awarded: £63,628

Location: University of Glasgow, Scotland
Project Title:  The E5 oncoprotein of human papillomavirus type 16 down - regulates the major histocompatibility class I complex
Funds Awarded: £135,323

Location: Queen Mary University of London, England
Project Title: Targeting CXCR4 and its ligand in ovarian cancer
Funds Awarded: £201,042

Location: University of Dundee, Scotland
Project Title: Regulation of p53 induction through transcription factor TAF1- mediated control of Mdm2.
Funds Awarded: £77,420

Location: Innsbruck Medical University, Austria
Project Title: Analysis of Bmf, a pro-apoptotic Bcl-2 family member, in cell death and tumorigenesis
Funds Awarded: £178,375

Location: University of Cambridge, England
Project Title: Elucidation of the oncogenic potential of Fbxo7 in hematopoietic malignancies
Funds Awarded: £166,711

Location: Pennsylvania State University, United States of America
Project Title:  Interaction of MLL (mixed Lineage Leukemia Factor) and related SET-domain proteins with active chromatin structures
Funds Awarded: £131,515

Location: University of Marburg, Germany
Project Title: Systematic identification of critical Myc target genes and genes that are synthetic lethal with deregulated Myc
Funds Awarded: £163,748

Location: University of Leeds, England
Project Title: A chromosomal translocation mimic for a Ewing's sarcoma model
Funds Awarded: £163,395

Location: University of Cambridge, England
Project Title: Genes required for Notch-induced over-proliferation
Funds Awarded: £82,555

Location: Erasmus Medical Centre, The Netherlands
Project Title: Rad17 at the crossroads of cell cycle checkpoints, DNA repair and mutagenesis in mammals?
Funds Awarded: £166,737

Location: Instituto Superiore di Sanita, Italy
Project Title:  The carcinogenicity of DNA damage produced by the immunosuppressant Azathioprine combined with UVA
Funds Awarded: £133,174

Location: University of Firenze, Italy
Project Title: Study of the role of hERG K+ channels in tumour progression of colorectal cancer
Funds Awarded: £123,000

Location: University of Torino, Italy
Project Title: Genetic and functional analysis of MLK4 in human cancer
Funds Awarded: £105,277

Location: IFOM, Milan, Italy
Project Title: RECQ helicases and genome intergrity: dissecting the function of Sgs1/BLM sumoylation in counteracting genotoxic recombination events during chromosome replication
Funds Awarded: £107,940

Location: IFOM, Milan, Italy
Project Title: The role of Ras in the induction of genome instability by aberrant DNA-replication
Funds Awarded: £90,011

Location: VIB-Ghent University, Belgium
Project Title:  EMT inducers driving malignant tumour progression by regulating angiogenesis and epithelial dedifferentiation
Funds Awarded: £126,428

Location: University of Vienna, Austria
Project Title: Role of B-Raf and Raf-1 in angiogenesis
Funds Awarded: £164,100

Location: Ludwig Institute for Cancer Research, England
Project Title: Investigating Bcl-2 and PP1 interactions to the ASPP family of proteins and their role in regulating apoptotic response
Funds Awarded: £151,994

Location: University of Cambridge, England
Project Title: The role of protein-DNA interactions in maintenance of imprinting at the Insulin-like Growth Factor 2 locus
Funds Awarded: £141,591

Location: University of Bradford, England
Project Title: Synthesis and evaluation of unnatural carbohydrates as potential anti-metastatic agents
Funds Awarded: £141,277

Location: University of Cardiff, Wales
Project Title:  In vivo analysis of the therapeutic and prophylactic potential of PARP inhibition
Funds Awarded: £223,313

Location: University of Basel, Switzerland
Project Title: Functional analysis of Tenascin-C and Tenascin-W in breast cancer mouse models
Funds Awarded: £130,269

Location: University of Dundee, Scotland
Project Title: Functional/mechanistic analysis and role in tumour development of the DEAD box protein p68, a novel transcriptional co-activator of the p53 tumour suppressor
Funds Awarded: £167,454

Location: Beatson Institute for Cancer Research, Scotland
Project Title: The role of GSK-3 in intestinal development, differentiation and tumourigenesis
Funds Awarded: £129,272

Location: Institute of Human Genetics, Newcastle, England
Project Title: Identification and characterisation of pre-mRNA splicing changes associated with the switch between hormone insensitive and sensitive prostate cancer
Funds Awarded: £118,737

Location: University of Edinburgh, Scotland
Project Title:  The putative role of proteolysis-inducing factor in prostate cancer
Funds Awarded: £100,005

Location: University of Parma, Italy
Project Title: A new animal model for prostate cancer: addressing the role of clusterin in tumor progression
Funds Awarded: £90,018

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