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Grants starting October 2004

Projects funded from October 2004

Location:  Cleveland Clinic Foundation, United States of America

Project Title:  Investigation of the Prognostic Value and role of fascin in colon carcinoma

Funds Awarded:  £130,346

 

Location:  University of Dundee, Scotland

Project Title:  Regulation and function of the LKB1 tumour suppressor

Funds Awarded:  £125,993

 

Location:  Imperial College of Science Technology & Medicine, England

Project Title:  Modulation of Estrogen Receptor activity by protein kinase A: Mechanisms and significance for breast cancer

Funds Awarded:  £84,820

 

Location:  European Institute of Oncology, Italy

Project Title:  Functional interactions between Myc and Wnt signalling in transcriptional regulation and cancer

Funds Awarded:  £86,508

 

Location:  University of Exeter, England

Project Title:  Role of Mcm 10 in the initiation of DNA replication

Funds Awarded:  £116,900

 

Location:  San Raffele Research Institute, Italy

Project Title:  The role of HMGB1 in tumour growth

Funds Awarded:  £95,163

 

Location:  University of Southampton, England

Project Title:  Regulation of Hdm2 oncoprotein expression by mitogenic signalling pathways

Funds Awarded:  £129,651

 

Location:  University College London, England

Project Title:  Coordination between junction disassembly and cell motility in human keratinocytes

Funds Awarded:  £83,700

 

Location:  University of Glasgow, Scotland

Project Title:  critical molecular pathways in cell transformation and immune evasion by E6 and E7 proteins of Group B1 cutaneous human papillomaviruses associated with non-melonoma skin cancer

Funds Awarded:  £245,970

 

Location:  Fondazione Italiana per la Ricerca sul Cancro, Italy

Project Title:  NCAM-mediated modulation of B, integrin in tumor progression

Funds Awarded:  £87,501

 

Location:  Cancer Research UK Paterson Institute, England

Project Title:  Lipidomic Analysis of Metastatic Prostate Cancer

Funds Awarded:  £114,571

 

Location:  University of Leeds, England

Project Title:  Transgenic mouse models for studying activation of autocrine growth factor genes by the BCR-ABL oncogene

Funds Awarded:  £149,238

 

Location:  University of Southampton, England

Project Title:  Mechanism of CD20 included apoptosis

Funds Awarded:  £133,020

 

Location:  University of Sussex, England

Project Title:  Roles of 53BP1 in DNA double-strand break repair

Funds Awarded:  £134,627

 

Location:  Institut Curie, France

Project Title:  Study of the molecular mechanisms involved in the transforming properties of the FLI-1 oncoprotein

Funds Awarded:  £139,500

 

Location:  Beatson Institute for Cancer Research, Scotland

Project Title:  Identifying mitochondria-generated signals that trigger tumourigenesis:  a link between the inhibition of the tricarboxylic acid cycle and cancer

Funds Awarded:  £127,976

 

Location:  University Amedeo Avogadro of Piemonte Orientale, Italy 

Project Title:  The role of a-Dicyglycerol kinase in HGF-adhesion-and-v-Src induced migratory and invasive signalling

Funds Awarded:  £22,565

 

Location:  Medizinische Hochschule Hannover, Germany

Project Title:  idenification and characterisation of CD4+ T cell in renal cell carcinoma

Funds Awarded:  £158,682

 

Location:  University of Bristol, England

Project Title:  Cyclooxygenase 2 and prostaglandin E2 as targets for fenretinide in oral cancer prevention

Funds Awarded:  £122,475

 

Location:  University of Manchester, England

Project Title:  An investigation into the oncogenic properties of the PDZ protein Tip-1

Funds Awarded:  £123,119

 

Location:  Medical Research Council, England

Project Title:  The WT1 - b-catenin connection in wilms' tumors

Funds Awarded:  £153,339

 

Location:  Erasmus University Rotterdam, The Netherlands

Project Title:  Tumour suppressor function of the signalling molecules Btk and SLP-65 in pre-B cells

Funds Awarded:  £153,104

 

Location:  The University of Durham, England

Project Title:  The role of lamin A in gene regulation in adrenal cortex carcinoma cell lines

Funds Awarded:  £189,181

 

Location:  Imperial College School of Medicine at Hammersmith Campus, England

Project Title:  Role & regulation of FOXO transcription factors in hormone dependent & antiestrogen resistant breast cancer

Funds Awarded:  £135,765

 

Location:  University of Dundee, Scotland

Project Title:  The nuclear localisation of the PTEN tumour suppressor: cellular function and regulation

Funds Awarded:  £72,888

 

Location:  University of Sheffield, England

Project Title:  Characterization of a fragment of human fibrinogen, fibrinogen E-Fragment with selective cytotoxicity for activated endothelial cells

Funds Awarded:  £129,625

 

Location:  University of Durham, England

Project Title:  Role of syndecan-1 in epidermal cell migration and proliferation

Funds Awarded:  £123,552

 

Location:  University of the Basque Country School of Medicine, Spain

Project Title:  Transcriptional regulation of DDR2 receptor in the tumor-associated myofibroblasts in primary & metastatic cancer

Funds Awarded:  £40,100

 

Location:  St George's Hospital Medical School, England

Project Title:  Protecting heamopoietic stem cells and blocking leukeamic cell growth using a cell permeable HOX/PBX interfering peptides

Funds Awarded:  £95,514

 

Location:  University of Birmingham, England

Project Title:  Proteomic analysis of the contribution of the Epstein-Barr virus to the pathogenesis of Hodgkin's lymphoma

Funds Awarded:  £124,300

 

Location:  King's College London, England

Project Title:  Structure-function studies of the p53 homologous protein p73

Funds Awarded:  £83,700

 

Location:  University of Dundee, Scotland

Project Title:  PPARo as a drug target in prostate cancer

Funds Awarded:  £114,983

 

Location:  King's College Hospital, England

Project Title:  Rapid Early Detection of Residual Cancer

Funds Awarded:  £144,755

 

Location:  University of Birmingham, England

Project Title:  Epstein-Barr virus and carcinogenesis:  a novel in vitro system to study the mechanism of viral entry into human epithelial cells

Funds Awarded:  £126,628

 

Location:  Leiden University Medical Centre, The Netherlands

Project Title:  Elucidation of the molecular and cellular mechanisms underlying desmoid disease (aggressive fibromatosis)

Funds Awarded:  £144,713

 

Location:  Newcastle University, England

Project Title:  Regulation of HDAC1; a component of the androgen receptor transcriptosome and potential therapeutic target in prostate cancer

Funds Awarded:  £129,660

 

Location:  University of London, England

Project Title:  Targeting the p53/MDM2 interaction.  Analogues of chlorofusin as potential antitumour agents

Funds Awarded:  £124,467

 

Location:  University of Aberdeen, Scotland

Project Title:  Mechanisms responsible for changes in FDG uptake by tumours responding to conventional and to novel therapy

Funds Awarded:  £66,695

 

Location:  Free University of Brussels, Belgium

Project Title:  Role of osteopontin and its receptors in the tumor-host interactions in multiple myeloma

Funds Awarded:  £65,400

 

Location:  Babraham Institute, England

Project Title:  Mechanisms of heterochromatin remodelling for DNA replication

Funds Awarded:  £125,762

 

Location:  University of Cambridge, England

Project Title:  The role of Stat3 isoforms in regulating apoptosis and tumourigenesis

Funds Awarded:  £156,295

 

Location:  University of Oxford, England

Project Title:  Dissecting the growth regulatory functions of the ski/sno oncogene family in drosophila

Funds Awarded:  £125,808

 

Location:  Erasmus MC, The Netherlands

Project Title:  The human genome maintenance complex Rad50/Mre11/Nbs1:  Analysis of structural requirements for oligomerization and DNA tethering activity

Funds Awarded:  £151,779

 

Location:  Marie Curie Research Institute, France

Project Title:  Mechanisms of the APC/C dependent ubiquitylation And proteolsis

Funds Awarded:  £129,314

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