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Grants starting October 2003

Projects funded from October 2003

Location: Institute of Cancer Research, England
Project Title: Non-invasive Monitoring of response to novel P13K-targeted therapeutic agents by magnetic resonance spectroscopy
Funds Awarded: £125,692

Location: Lund University, Sweden
Project Title: Heparan sulfate and polyamines as targets for antitumor therapy
Funds Awarded: £127,914

Location: University of Goteborg, Sweden
Project Title: Angiogenesis in tumors: Roles of endothelial guidance and pericyte recruitment.
Funds Awarded: £155,500

Location: MRC Laboratory of Molecular Biology, England
Project Title: The nuclear export function of the APC tumour suppressor
Funds Awarded: £188,763

Location: University of East Anglia, England
Project Title: Characterisation of Non-homologous End-joining of DNA in bacteria
Funds Awarded: £35,522

Location: International Agency for Research on Cancer (IARC), France
Project Title: The role of DNA repair and cell cycle control gene polymorphisms in the development of lung cancer
Funds Awarded: £109,294

Location: Forschungszentrum Karlsruhe, Germany
Project Title: Modulation of androgen receptor action in prostate carcinoma cells by the coactivator Bag-1L
Funds Awarded: £152,997

Location: Cardiff University, Wales
Project Title: Stat3 and tumour suppression, investigating roles in mammary and intestinal epithelia
Funds Awarded: £189,988

Location: International Agency for Research on Cancer (IARC), France
Project Title: Multicentre study of genetic and environmental determinants of Nasopharyngeal Carcinoma in the endemic region of North Africa
Funds Awarded: £96,650

Location: University of Newcastle upon Tyne, England
Project Title: Investigation of the therapeutic potential of novel CDK inhibitors in prostate cancer
Funds Awarded: £83,545

Location: University of Edinburgh, Scotland
Project Title: Exploiting an unique opportunity to study the earliest consequences of tumour suppressor loss in a real tissue
Funds Awarded: £138,765

Location: Institut Pasteur, France
Project Title: SUMO Modification and the Acute Promyelocytic Leukemia-Associated PML Nuclear Bodies
Funds Awarded: £132,000

Location: University of Leicester, England
Project Title: Functions of BCL11A and BCL11B in B- and T-cell malignancies
Funds Awarded: £133,312

Location: University of Dundee, Scotland
Project Title: Translational regulation of p53 expression
Funds Awarded: £118,365

Location: University of Cambridge School of Clinical Medicine, England
Project Title: A sibling pair study to identify Barrett's oesophagus susceptibility genes
Funds Awarded: £86,000

Location: Medical Research Council Laboratory of Molecular Biology, England
Project Title: Control of cell proliferation by intercellular signalling
Funds Awarded: £135,414

Location: University of Dundee, Scotland
Project Title: SUMO-2 modification of the "DEAD box" protein p68: Functional analysis and role in tumour development
Funds Awarded: £72,150

Location: National Institute for Medical Research, England
Project Title: Structural and functional analysis of chromatin regulation by histone methyltransferases and implications for anti-cancer drugs
Funds Awarded: £134,588

Location: Tel Aviv University, Israel
Project Title: Antagonistic activity of the human frizzled 6 (Hfz6) receptor on Wnt signaling
Funds Awarded: £89,200

Location: The University of Kent at Canterbury, England
Project Title: The Role of the Neuregulin gene family in Prostate Cancer
Funds Awarded: £124,444

Location: University of Leeds, England
Project Title: Identification of target(s) for chemoprevention of colorectal cancer by indomethacin
Funds Awarded: £120,225

Location: European Institute of Oncology, Italy
Project Title: Role of the Polycomb gene EZH2 in cancer and cell proliferation
Funds Awarded: £117,763

Location: International Agency for Research on Cancer, France
Project Title: Functional & genetic study of Trrap in oncogenic transformation & tumour development
Funds Awarded: £89,890

Location: Hammersmith Hospital, England
Project Title: Identification of AP-2y target genes in breast tumour derived cell lines using ChIP
Funds Awarded: £138,971

Location: University College London, England
Project Title: Regulation of HPV variant gene expression and cervical carcinogenesis by the Brn-3a transcription factor
Funds Awarded: £120,774

Location: National Institute for Medical Research, England
Project Title: The role of NF-kB2 in cell transformation by the EBV Latent Membrane Protein 1
Funds Awarded: £132,932

Location: Richard Dimbleby / Cancer Research UK Labs, England
Project Title: Use of a novel organotypic transplantation model to determine role of the integrin xvb6 in SCC invasion in vivo
Funds Awarded: £140,413

Location: Trinity College, University of Dublin, Ireland
Project Title: Development of novel calix (4) sugars as lectin-specific drug delivery systems
Funds Awarded: £75,843

Location: The University of Hong Kong, Hong Kong 
Project Title: Characterization of novel tumour suppressor genes, DLC1 and DLC2 genes, in liver cancer
Funds Awarded: £112,500

Location: University of London, England
Project Title: The role of Ax1, a receptor tyrosine kinase, in epidermal squamous carcinogenesis
Funds Awarded: £84,190

Location: University of London, England
Project Title: Synthesis & evaluation of covalently dimerised redox-sensitive peptide conjugates as AP-1 transcriptional factor inhibitors
Funds Awarded: £84,743

Location: European Institute of Oncology, Italy
Project Title: Role of Nucleophosmin in tumor development
Funds Awarded: £92,287

Location: University of Dundee, Scotland
Project Title: The cellular function of SNIP1, a nuclear repressor of p53 and NF-kB transcriptional activity
Funds Awarded: £34,130

Location: University College London, England
Project Title: Regulation of cell proliferation and transformation by RhoE/Rnd3
Funds Awarded: £133,876

Location: Peter MacCallum Cancer Institute, Australia
Project Title: The role of the D1g/Scrib/Lg1 pathway in cancer
Funds Awarded: £123,316

Location: The Hebrew University of Jerusalem, Israel
Project Title: P53 involvement in apoptosis and cell cycle arrest - a functional genomic approach
Funds Awarded: £144,866

Location: University of Patras, Greece
Project Title: Geminin, a negative regulator of cell division: gene inactivation in mice and functional analysis
Funds Awarded: £66,713

Location: University College London, England
Project Title: Characterisation of the protein kinase activity of PI 3-kinase
Funds Awarded: £127,776

Location: Cancer Research UK London Institute, England
Project Title: Mapping the role of Beta-catenin in stem cell fate and tumourigenesis within the mammalian epidermis
Funds Awarded: £38,448

Location: St Andrews University, Scotland
Project Title: Functional characterisation of the archaeal Nucleotide Excision Repair protein XPF
Funds Awarded: £60,950

Location: Hebrew University - Hadassah Medical School, Israel
Project Title: The role of VICKZ proteins in cell migration and metastasis in colorectal carcinoma cells
Funds Awarded: £99,535

By funding only the best science, we ensure that we have the highest chance of making significant progress.  Applications for funding are peer reviewed by our Scientific Advisory Committee and many are also sent to two experts in the field for external review.

 

 

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