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Reasons to Support AICR

  1. Dr Andrew Chantry (Norwich, England) identified a ‘rogue’ gene called WWP2 which allows cancer cells to spread.  He is now developing drugs to turn off WWP2 and therefore prevent cancers from spreading. 
  2. Professor Eric So (London, England) discovered that leukaemic stem cells can be reversed to a pre-leukaemic stage by turning off a protein called beta-catenin found in the blood.  He also found that advanced leukaemic stem cells that had become resistant to treatment could be ‘re-sensitised’ to treatment by suppressing the same protein.  Together these are a critical step forward in the search for more effective treatments for aggressive forms of leukaemia.
  3. Dr Miguel Godinho Ferreira (Oeiras, Portugal) has discovered how cells protect the ends of their chromosomes using telomeres whilst avoiding a DNA damage response.
  4. Dr Tim Greten (Hannover, Germany) has identified key molecules involved in the development of serrated bowel cancer. 
  5. Dr Gareth Inman (Dundee, Scotland) has discovered how the TGF- molecule is able to switch between its anti-cancer and cancer promoting abilities.
  6. Dr John Rouse (Dundee, Scotland) has discovered a group of proteins that act like a 'Swiss Army Knife' to repair damaged DNA in our cells.
  7. Dr John Martens (Rotterdam, The Netherlands) identified a molecule that can help identify which breast cancer patients will respond better to tamoxifen therapy.
  8. Dr Daniel Ndisang (London, UK) discovered why women infected with the HPV virus and smoke are twice as likely to develop cervical cancer than non-smokers. Have paper in grants system.
  9. Dr Daniel Ndisang (London, UK) revealed a potential new way of screening for cervical cancer which is cheaper than current screening methods.
  10. Professor David MacEwan (East Anglia, England) revealed a potential new way to treat chemotherapy resistant forms of Acute Myeloid Leukaemia (AML).
  11. Professor Jonathan Sleeman (Heidelberg, Germany) identified a key protein that encourages cancer spread and correlates with poor survival in bowel cancer patients.
  12. Dr Núria Malats (Spanish National Cancer Centre, Spain) identified the trace mineral selenium, found in bread and meat, may help prevent bladder cancer, especially in women.
  13. Professor Andrew Cato (Karlsruhre, Germany) in a previous AICR grant he found the molecule Bag-1L works to increase the size of prostate tumours.  With his current grant he is looking for drugs to turn off Bag-1L and therefore prevent prostate cancers from growing.
  14. Professor Tomo Tanaka (Dundee, Scotland) has uncovered how cells ensure correct inheritance of their genetic information in order to prevent diseases like cancer.
  15. Dr Paul Walker (Geneva, Switzerland) discovered that the immune system is defective in fighting the early stages of brain tumours so future treatments could be designed to boost this anti-cancer immune response.
  16. Professor Clare Isacke (London, England) has found a potential new way to increase the effectiveness of tamoxifen for women with breast cancer who have become resistant to the treatment.
  17. Professor Aart Jochemsen (Leiden, the Netherlands) has found that the protein Mdm4 can protect cancer cells from dying when treated with chemotherapy.
  18. Dr Maria Rescigno (Milan, Italy) discovered that the protein TLR4 which is involved in inflammatory responses also has a role in the development of skin cancer. 
  19. Professor Vincent Goffin (Paris, France) identified two new molecules that are involved in the initiation of prostate cancer.
  20. Dr Chris Ward (Manchester, England) has uncovered a new way to investigate how cancer cells start to spread around the body. 
  21. Dr Ofer Mandleboim (Jerusalem, Israel) has identified several molecules which were present at high levels in cancer cells and were able to help the tumours avoid being detected and attacked by the immune system.
  22. Dr Bertrand Huard (Geneva, Switzerland) has discovered a way in which tumours prevent our immune system from attacking them.
  23. Professor Robin Anderson (Melbourne, Australia) has identified factors which dictate where in the body breast cancer cells are likely to spread to.
  24. Professor Saverio Bettuzzi (Parma, Italy) has discovered a new protein that is involved in preventing prostate cancer.
  25. Dr Dimitris Xirodimas (Dundee, Scotland) has discovered exactly why a group of commonly used cancer drugs are so effective at fighting the disease.
  26. Professor Martin Eilers (Wuerzburg, Germany) revealed a potential new way to treat neuroblastoma, a type of childhood cancer of the nervous system.
  27. Professor Alberto Bardelli (Milan, Italy) identified a protein that is responsible for the different responses bowel cancer patients have to drug treatments.
  28. Dr Michaela Aldred (Cleveland, USA) has identified a gene responsible for some cases of Wilms tumours, a type of childhood kidney cancer
  29. Dr Mark Cragg (Southampton, England) has discovered how the antibody treatment Rituximab works to kill leukaemia cells.
  30. Dr Rohini Kuner (Heidelberg, Germany) has discovered that cancer pain works by a different mechanism from normal pain which paves the way for the development of new pain relief drugs.
  31. Professor Chris Hutchison (Durham, England) discovered a potential marker to identify aggressive bowel cancers
  32. Dr Joanne Edwards (Glasgow, Scotland) has identified changes in prostate cancer cells which are involved in them becoming resistant to hormone therapy.
  33. Professor Lambert Dorssers (Rotterdam, The Netherlands) has identified a new gene associated with resistance to the main drugs used to treat breast cancer.
  34. Dr Bohdan Wasylyk (Stasbourg, France) has discovered a small molecule which, after further work, could potentially help stop the growth of new blood vessels and kill tumours.
  35. Dr Jean-Christophe Marine (Brussels, Belgium) has identified a key molecule involved in retinoblastoma, a type of childhood eye cancer and found a new drug combination to treat it.
  36. Professor Marco Falasca (London, England) discovered a mechanism involving the protein PLCg1 that can stop breast cancer spreading, one of the things that makes cancer so dangerous.
  37. Dr Tim Greten (Hannover, Germany) has discovered a potential new way to make a patient’s own immune system attack and kill their liver tumours.
  38. Professor Eric So (London, England) has revealed a potential new way to treat an aggressive type of leukaemia. 
  39. Dr Tatiana Petrova (Helsinki, Finland) has found that high levels of a protein called PROX1 is associated with developing bowel cancer.
  40. Dr John Martens (Erasmus, The Netherlands) has identified 4 molecules which are linked to aggressiveness in a type of breast cancer.
  41. Dr David Waugh (Belfast, Northern Ireland) found the molecule IL-8 has a key role in allowing prostate cancer cells to become resistant to the common drug treatments.
  42. Professor Vincent Goffin (Paris, France) developed a drug that, in the laboratory, blocks a hormone called prolactin that encourages the growth of prostate tumours. 
  43. Professor Olivier Delattre (Paris, France) identified the type of cells that give rise to Ewing’s Sarcoma, a type of bone cancer.
  44. Dr James Ross (Edinburgh, Scotland) found two molecules: DCD and PIF-CP play a role in allowing prostate cancer cells to survive in the prostate microenvironment. 
  45. Professor John Mann (Belfast, Ireland) used compounds based on a plant historically used in African folk medicine for its anti-malarial properties, to understand how cancer cells can be forced to fold up and die.
  46. Dr Stewart Martin (Nottingham, England) has developed a potential new drug to kill bowel, kidney and breast cells in the laboratory by tackling the cells that make a blood supply for the tumours.
  47. Professor Gordon Jayson (Manchester, England) discovered a complex natural sugar from the glucose family of sugars which can block the growth of tumours in tests done in mice.
  48. Dr Colin Goding (Oxford, England) found a way to put cancer cells into a permanent coma by turning on a natural self defence mechanism.
  49. Professor Malcolm White (St Andrews, Scotland) used tiny microbes called archaea and found that proteins called helicases contain iron-sulphur clusters which are involved in preventing cancer.
  50. Dr Eric Adams (Aston, England) identified a change in a gene called catenin which is involved in craniopharyngioma tumours, a type of childhood brain cancer. 
  51. Professor David Kelsell (London, England) showed that cells in over 90% of patients with the commonest form of skin cancer have genetic damage in the same place.  They found the gene called ‘Patched’ is the ‘first hit’ in a chain of events in that leads to skin cancer.
  52. Professor Dario Alessi (Dundee, Scotland) found evidence that Metformin, a drug commonly used for diabetes, may also help prevent cancer. 
  53. Dr Igor Bronstein (York, England) used nanotechnology to identify a molecule that can help make cancer cells resistant to chemotherapy.
  54. Dr Richard Wheelhouse (Bradford, England) has developed several potential new drugs designed to kill cancer cells instead of normal cells.
  55. Professor Per Lindahl (Göteborg, Sweden) has identified a key component that controls the growth of new blood vessels to supply tumours with blood. 
  56. Dr Judy Coulson (Liverpool, England) discovered a new, altered form of a protein which is present at high levels in small cell lung cancer and in the future could be used as a marker to detect the disease at an early stage.
  57. Dr Mariann Bienz (Cambridge, England) has identified a protein that helps prevent bowel cells from becoming cancerous.
  58. Dr Agnes Klochendler (Jerusalem, Israel) has identified the genes responsible for malignant rhabdoid tumour, a type of childhood kidney cancer.    
  59. Dr Marilys Corbex (Lyon, France) has identified several lifestyle factors associated with nasopharyngeal carcinoma, a common type of nose and mouth cancer in North Africa.
  60. Dr Alain Verrault (Montréal, Canada) discovered one way yeast cells escape death from chemotherapy by repairing the DNA damage caused by the drugs.
  61. Dr Stefan Roberts (Oxford, England) discovered a protein that can ‘clean’ cancer cells to remove a dangerous cancer causing gene.
  62. One of, if not the very first grant we awarded was in 1980, to Dr P R Salmon of University College Hospital, who was awarded a one-year grant to study photodynamic therapy – the use of lasers and light-sensitive drugs to treat cancer.  The research we funded, along with a number of other research projects, lead to the first use of photodynamic therapy on patients in 1981 and the establishment of the National Medical Laser Centre at UCH in 1984.
 

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