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Grants starting April 2006

Projects funded from April 2006

Location: University of Cambridge, England
Project Title: Regulatory dendritic cells:  control by LILR receptors
Funds Awarded: £83,407

Location: Marie Curie Research Institute, England
Project Title: An INK4a/ARF - independent senescence pathway in melanoma as a potential therapeutic target
Funds Awarded: £136,770

Location: Institute of Cancer Research, England
Project Title: Molecular pathology of chemically-induced urothelial cancer
Funds Awarded: £140,027

Location: University of Dundee, Scotland
Project Title: Control of antioxidant genes by the Nrf1 transcription factor and regulation of its activity by cancer chemopreventive agents
Funds Awarded: £156,066

Location: University of Leicester, England
Project Title: Regulation of protein destruction in mitosis
Funds Awarded: £155,210

Location: Imperial College of Science Technology & Medicine, England
Project Title: Regulation of gene expression by mammalian Lin-9 and its interaction with the B-Myb transcription factor
Funds Awarded: £163,980

Location: University of Newcastle upon Tyne, England
Project Title: Poly (ADP-ribose) polymerase pharmacogenetics and expression analysis in patients receiving anticancer therapy
Funds Awarded: £77,410

Location: University of Leeds, England
Project Title: The expression and function of FGFR1 in urothelial
Funds Awarded: £137,295

Location: University of Dundee, Scotland
Project Title: Roles of microtubule plus-end-tracking proteins in kinetochore-microtubule interactions
Funds Awarded: £166,725

Location: University of Dundee, Scotland
Project Title: Combined biochemical & genetic approach to elucidate Sir-2 histone deacetylase function in C. elegans DNA damage induced apoptosis
Funds Awarded: £81,030

Location: The Institute of Cancer Research, England
Project Title: Antagonism of anti-B-RAF and anti-MEK therapies by TNFalpha in melanoma
Funds Awarded: £145,949

Location: University of Nottingham, England
Project Title: Structure-guided design of eIF4E mRNA cap-binding antagonists as cancer drug candidates
Funds Awarded: £122,332

Location: University College London, England
Project Title: Novel small molecule transporters of proteins conjugated to the DNA synthesis inhibitor protein geminin:  optimization of the in vitro anti-tumour activity of exogenously applied geminin-conjugates
Funds Awarded: £83,352

Location: University of Dundee, Scotland
Project Title: Regulation of the DNA damage-induced interaction of 53BP1-hPTIP and consequences for responses to double strand breaks
Funds Awarded: £122,123

Location: University of Cardiff, Wales
Project Title: Isolation of modifiers of Wnt and P53 pathways in Xenopus embryos
Funds Awarded: £43,344

Location: The Hebrew University of Jerusalem, Israel
Project Title: Dissecting the interaction between the DNA damage mediators, MDC1 and 53BP1
Funds Awarded: £62,350

Location: Austin Research Institute, Australia
Project Title: The role of the tetraspanin CD37 in anti-tumour immunity
Funds Awarded: £117,790

Location: University of Uppsala, Sweden
Project Title: Molecular mechanisms of glioma development
Funds Awarded: £159,371

Location: CNRS, France
Project Title: Finding modulators of RUNX and GATA transcriptional activity by a genome-wide RNAi screen
Funds Awarded: £113,700

Location: University of Leuven, Belgium
Project Title: Tumour angiogensis and the role of tumour-spectific endothelial cell protein,endosialin
Funds Awarded: £156,705

Location: National Cancer Institute, Israel
Project Title: A Gene therapy approach to impair tumour growth and invasion acting on p27kip1/ stathmin interaction
Funds Awarded: £110,700

Location: The University of Crete Medical School, Greece
Project Title: Molecular mechanisms regulating the sensitivity of carcinoma cells to CD40 ligand-induced apoptosis and the cross-talk with the integrin network
Funds Awarded: £81,827

Location: Institut de Recerca Hospital Universitari Vall d' Hebron, Spain
Project Title: Role of FoxG1 in glioma
Funds Awarded: £107,719

Location: University Medical Centre Utrecht, The Netherlands
Project Title: Mechanisms for antibody-thetapeutics of cancer
Funds Awarded: £152,265

Location: IFOM, Italy
Project Title: Genetic analysis of epsin function in mammals
Funds Awarded: £92,958

Location: University of Copenhagen, Denmark
Project Title: Functional analysis of a novel SET domain tumour suppressor protein
Funds Awarded: £152,240

Location: University of California Los Angeles, United States of America
Project Title: Investigation of the molecular mechanisms underlying oncogenic transformation induced by notch signaling
Funds Awarded: £104,546

Location: Insituto Gulbenkian de Ciencia, Portugal
Project Title: End-protection and DNA repair at s. pombe telomeres
Funds Awarded: £130,681

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