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Grants starting April 2003

Projects funded from 1 April 2003

Location: Liverpool John Moores University, England
Project Title: Exploitation of deregulated tumour glucose transport and metabolism for novel anticancer strategies
Funds Awarded: £127,750

Location: Instituto de Investigaciones Biomedicas, Spain
Project Title: Regulation of proto-oncogenic Cot kinase activity by extracellular signals. Implication of Cot kinase activity in apoptosis
Funds Awarded: £72,090

Location: Imperial College of Science Technology & Medicine, England
Project Title: "Phosphoinositide 3-kinases in the control of proliferation and survival of small cell lung cancer"
Funds Awarded: £138,343

Location: Cancer Research UK, England
Project Title: Regulation of hif-1activity and function
Funds Awarded: £131,378

Location: Justus-Liebig-University, Germany
Project Title: Novel strategies for androgen receptor inactivation in prostate cancer
Funds Awarded: £151,230

Location: University of Oxford, England
Project Title: Gene expression profiling in polycythaemia rubra vera using cDNA microarray technology
Funds Awarded: £130,639

Location: University of Sheffield, England
Project Title: Photodynamic therapy-induced tumour imunity: A role for heat shock proteins?
Funds Awarded: £140,935

Location: St George's Hospital Medical School, England
Project Title: Analysis of the human TTC4 protein, its role in the control of DNA replication proteins and its relationship to the development of malignant melanoma
Funds Awarded: £153,870

Location: Garvan Institute of Medical Research, Australia
Project Title: The role of the Gab2 docking protein in human breast cancer
Funds Awarded: £106,705

Location: INSERM U 509, Institut Curie, France
Project Title: Characterisation of EWS and EWS-FLI-I associated proteins. Role of these interactions in the oncogenesis of Ewing tumours
Funds Awarded: £81,012

Location: University of Manchester, England
Project Title: Understanding the activation of pro-apoptotic proteins bid and bax in order to develop novel therapeutic approaches that lower the threshold for drug-induced apoptosis in tumour cells
Funds Awarded: £48,886

Location: University of Dundee, Scotland
Project Title: Is the tumour specific expression of cytochrome P450 CYP1B1 caused by post-transcriptional mechanisms?
Funds Awarded: £66,750

Location: Institut Curie, France
Project Title: Study of the molecular mechanisms involved in TEL-JAK2 induced leukaemia
Funds Awarded: £145,250

Location: University of Glasgow & The Beatson Institute for Cancer Research, Scotland
Project Title: Genetic analysis of the role and mechanism of Chk1 regulation in the replication and DNA damage checkpoints and in determining tumour cell survival in response to anti-cancer drugs
Funds Awarded: £133,494

Location: Forschungszentrum Karlsruhe, Germany
Project Title: Control of histone deacetylase-2 (HDAC-2) by the APC tumour suppressor and its implications in colon carcinogenesis
Funds Awarded: £147,980

Location: King's College London, England
Project Title: Harnessing the allergic reaction to combat ovarian cancer
Funds Awarded: £170,571

Location: University of Bristol, England
Project Title: Bag-1 proteins in oral carcinogenesis: evaluation of the implications for chemoprevention and therapy
Funds Awarded: £129,854

Location: University of Dundee, Scotland
Project Title: Contribution of Nrf1 isoforms to regulation of the ARE-gene battery by cancer chemopreventive blocking agents
Funds Awarded: £123,303

Location: Danish Cancer Society, Denmark
Project Title: Lysosomal Hsp70 as a target for cancer therapy
Funds Awarded: £158,109

Location: Cancer Research UK, England
Project Title: Using inducible clonal targeting to analyse the function of Notch in normal and premalignant intestinal stem cells
Funds Awarded: £148,556

Location: The Hebrew University-Hadassah Medical School, Israel
Project Title: SNF5 conditional mutation, a mouse model for childhood malignant rhabdoid tumour
Funds Awarded: £140,170

Location: Brunel University, England
Project Title: Molecular basis of genetic instability in tetranucleotide repeats in human cancers
Funds Awarded: £35,239

Location: The Hong Kong University of Science & Technology, Hong Kong
Project Title: Molecular characterisation of the EWS oncogene and evaluation of potential peptide inhibitors
Funds Awarded: £85,892

Location: University Medical Centre Utrecht, The Netherlands
Project Title: Antibody dependent tumour lysis by FcxRI (CD89) is regulated by Mac-1 (CD11b/CD18): dissection of signalling pathways
Funds Awarded: £126,450

Location: Consejo Superior de Investigacions Cientificas, Spain
Project Title: Molecular mechanisms regulating the sensitivity of breast tumour cells to TRAIL-induced apoptosis
Funds Awarded: £89,270

Location: University of Aberdeen, Scotland
Project Title: Structural and functional analysis of the androgen receptor amino terminal domain: role of protein-protein interactions
Funds Awarded: £61,050

Location: University of Dundee, Scotland
Project Title: Phosphorylation of the Hdm2 protein at the critical serine 260 and 262 residues: signalling mechanism(s) and role in regulating the p53 response
Funds Awarded: £110,957

Location: Garvan Institute of Medical Research, Australia
Project Title: Identification and functional analysis of oestrogen-induced c-Myc target genes in breast cancer cells
Funds Awarded: £117,573

Location: University of Dundee, Scotland
Project Title: How does the interplay between intra-and intermolecular interactions of the Adenomatous Polyposis Coli protein regulate its multiple functions in cancer?
Funds Awarded: £127,729

Location: University of Crete Medical School, Greece
Project Title: Study of the in vivo effect of an anti-TNFx monoclonal antibody (cA2) on bone marrow stem/progenitor cell reserve and function and on bone marrow stromal cell function in patients with myelodysplastic syndromes.
Funds Awarded: £39,000

Location: Imperial Cancer Research Fund, England
Project Title: Role of BAF57 and UPOC cofactor proteins in oestrogen action
Funds Awarded: £141,217

Location: Copenhagen University Hospital, Denmark
Project Title: C/EBPalpha in myeloid leukaemia
Funds Awarded: £161,745

Location: University of Manchester, England
Project Title: Identification of target genes for the TCF ETS-domain transcription factors
Funds Awarded: £140,297

Location: IGBMC, France
Project Title: The role of human TAFII68, EWS and TLS/FUS and their oncogenic derivatives in regulating transcription by RNA polymerase II
Funds Awarded: £115,251

Location: University of Crete, Greece
Project Title: Immunomodulation by tumour-derived neuropeptides
Funds Awarded: £66,101

Location: Erasmus University Rotterdam, The Netherlands
Project Title: Biological impact of cyclobutane pyrimidine dimers and 6/4 photoproducts induced by ultraviolet light
Funds Awarded: £129,266

Location: Cancer Research UK, England
Project Title: The role of the chemokine CXCL12 and its receptor CXCR4 in human ovarian cancer
Funds Awarded: £168,432

Location: The Austin Research Institute, Australia
Project Title: Growth inhibitory antibodies in colon cancer
Funds Awarded: £128,247

By funding only the best science, we ensure that we have the highest chance of making significant progress.  Applications for funding are peer reviewed by our Scientific Advisory Committee and many are also sent to two experts in the field for external review.

 

 

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