Projects funded from 1 October 2002
Location: Ben-Gurion University of the Negev, Israel
Project Title: IL-1 as a mediator of the angiogenic switch in tumours
Funds Awarded: £92,403
Location: VIB - Ghent University, Belgium
Project Title: Analysis of the Smad-interacting protein-1 (SIP1) as an invasion inducer in carcinomas
Funds Awarded: £106,117
Location: Imperial College of Science Technology & Medicine
Project Title: Functional characterisation of novel androgen receptor-interacting proteins.
Funds Awarded: £75,850
Location: Institute of Child Health
Project Title: Mechanisms mediating over-expression of the Brn-3b transcription factor in breast tumour
Funds Awarded: £112,560
Location: Salford University, England
Project Title: DT-Diaphorase Activated Anti-vasculature Agents
Funds Awarded: £68,415
Location: University of East Anglia, England
Project Title: Cross regulation of BCR-ABL and TGFB signalling pathways in chronic myeloid leukaemia
Funds Awarded: £64,050
Location: Marie Curie Research Institute
Project Title: Characterization of swil and swi3 mediated replication-termination, pausing and genome stability in fission yeast.
Funds Awarded: £168,366
Location: University of Sheffield, England
Project Title: Synergistic activation of apoptosis for cancer therapy
Funds Awarded: £114,062
Location: University College London, England
Project Title: Molecular mechanisms regulating sorting of ErbB receptors and the role of the endosome in regulating mitogenic signalling
Funds Awarded: £156,210
Location: University of Leicester, England
Project Title: Comparison of Pharmacokinetic and Pharmacodynamic Properties of Curcumin in Min Mice and Patients with Surgically Resectable Colorectal Cancer.
Funds Awarded: £107,349
Location: Marie Curie Research Institute
Project Title: Understanding transcription and signalling in melanoma as an approach to therapy
Funds Awarded: £122,934
Location: Campus de Cantoblanco
Project Title: Analysis of the tumour regulatory effect of APRIL, a TNF family member.
Funds Awarded: £131,544
Location: Erasmus University Rotterdam, The Netherlands
Project Title: Transcription factor GATA-3: a key regulator of proliferation and differentiation in T lymphocyte development
Funds Awarded: £128,300
Location: University of Dundee, Scotland
Project Title: Molecular Mechanisms of Wnt Protein Function and Inhibition of Wnt Protein Function in Development and Oncogenesis
Funds Awarded: £42,504
Location: University of Surrey, England
Project Title: Pharmacokinetics of the chemopreventive phytochemical sulphoraphane
Funds Awarded: £126,454
Location: Skirball Institute for Biomedical Research
Project Title: The role of tyrosine phosphatase SHP-1 in tumour suppression and T cell antigen receptor signaling
Funds Awarded: £91,271
Location: Imperial Cancer Research Fund
Project Title: The role of photoactivation of DNA 6-thioguanine in skin cancer in organ transplant recipients
Funds Awarded: £120,277
Location: University of Glasgow, Scotland
Project Title: A novel transcription co-activator complex for the p53 tumour suppressor protein
Funds Awarded: £67,050
Location: University of Birmingham, England
Project Title: Genetic and Functional analysis of RASSF1A tumour suppressor gene at 3p21.3
Funds Awarded: £128,561
Location: Ludwig Institute for Cancer Research
Project Title: Investigating the tumour suppression function of ASPP2 and its interaction with p53 in vivo
Funds Awarded: £153,524
Location: University of Edinburgh, Scotland
Project Title: An investigation into the role of APC in medulloblastoma
Funds Awarded: £116,990
Location: Texas A&M University System Health Science Centre, United States of America
Project Title: Functional Interactions of PIASy with STAT1 and an E2 Ubiquitin Conjugase in Cellular Transformation and Apoptosis.
Funds Awarded: £123,847
Location: National Cancer Institute
Project Title: Understanding Bmi-1 mediated Epigenetic Mechanisms in Tumourigenesis
Funds Awarded: £132,743
Location: European Molecular Biology Laboratory
Project Title: Characterization of RINGO, a novel family of proteins that regulate the activity of cyclin-dependent kinases (Cdks)
Funds Awarded: £113,946
Location: Medical Research Council
Project Title: A novel approach to selecting and maturing antibodies/ligands for directed cell targeting
Funds Awarded: £127,547
Location: Medical Research Council
Project Title: NMR Structure Determination of the DNA-Binding Domain of DNA ligase III and its Complex with Nicked DNA
Funds Awarded: £34,526
Location: University of Warwick, England
Project Title: Mouse models for investigating the oncogenic potential of c-Myc
Funds Awarded: £146,751
Location: University College London, England
Project Title: Regulation of dual-specificity phosphatases by cell stress
Funds Awarded: £73,050
Location: Gray Cancer Institute
Project Title: Imaging protein-protein kinetics in the activation pathways of NFkB and PKC: Modification by cancer treatment
Funds Awarded: £36,780
Location: University of Manchester, England
Project Title: Modulation of the Wilms' tumour suppressor protein function in vivo by synthetic peptides
Funds Awarded: £111,745
Location: University of Bern, Switzerland
Project Title: Molecular mechanisms of HIPK2 function in acute promyelocytic leukemia
Funds Awarded: £77,615
Location: Medical University of Ulm, Germany
Project Title: Role of the protein kinase D (PKD) family kinases PKD/protein kinase Cu (PKCu) & protein kinase D2 (PKD2) in gastrin-stimulated proliferation, apoptosis & invasion of human colon cancer cells
Funds Awarded: £80,669
Location: University of Edinburgh, Scotland
Project Title: Studies of the anti-tumour mechanisms of NSAIDs in colorectal cancer
Funds Awarded: £105,098
Location: University of Manchester, England
Project Title: Do truncating mutations in the adenomatous polyposis coli gene initiate chromosome instability in colorectal cancer?
Funds Awarded: £134,904
Location: Centre National de la Recherche Scientifique
Project Title: The study of Integrin-linked Kinase in Vascular Endothelial Cells: Role in Tumour Angiogenesis
Funds Awarded: £107,055
Location: University Hospital Geneva, Switzerland
Project Title: Immunotherapy for brain tumours: a critical balance between immunoprotection and immunopathology
Funds Awarded: £137,045
Location: Pasteur Institute
Project Title: Role of AP-1 in regulating the choice between cell survival and apoptosis
Funds Awarded: £137,804
