Projects funded from 1 April 2000
Location: University of Salamanca/CSIC, Spain
Project Title: Cellular mechanisms involved in the activation of the vav proto-oncogene product
Funds Awarded: £94,814
Location: University of Cambridge, England
Project Title: Role of the transcription factor Pax5 in locus accessibility and tumourigenesis
Funds Awarded: £135,423
Location: University of London, England
Project Title: The function of the BRK tyrosine kinase in breast tumour cells
Funds Awarded: £131,354
Location: University of Wales College of Medicine, Wales
Project Title: Effect of Mutant RAS on Gene Expression in Primary Human Haematopoietic Cells
Funds Awarded: £35,251
Location: University of Cambridge, England
Project Title: Biochemical and Structural Studies of the Mre11 Protein Complex
Funds Awarded: £114,397
Location: Josephine Nefkens Institute
Project Title: Characterisation of BCAR1/p130CAS in anti-oestrogen resistance of human breast cancer cells
Funds Awarded: £134,280
Location: Institute of Cancer Research
Project Title: Enhancer of split homologues in the regulation of normal and leukaemic haematopoiesis
Funds Awarded: £114,894
Location: University of St Andrews, Scotland
Project Title: Development of LT-B as a Mucosal Vaccine Delivery Vehicle for Tumour-Specific Carbohydrate Antigens
Funds Awarded: £50,464
Location: University College Dublin, Republic of Ireland
Project Title: The Role of Fibulins in Tumourigenesis - Value as Prognostic Indicators and Molecular Targets in Cancer Therapy
Funds Awarded: £55,300
Location: The University of Leeds, England
Project Title: Gene therapy for colorectal carcinoma utilising Herpesvirus saimiri-based vectors.
Funds Awarded: £58,440
Location: Marie Curie Research Institute
Project Title: The tbx2 transcription factor: its role in the recognition and modulation of chromatin during mitosis in melanocytes and melanoma.
Funds Awarded: £124,308
Location: IGBMC - BP 163
Project Title: Retroviral mutagenesis to identify genes critically involved in retinoid and glucocorticoid induced apoptosis.
Funds Awarded: £93,249
Location: European Institute of Oncology
Project Title: Phenotype screening for gene products that can overide effects of p53 and chemotherapeutic agents on cell proliferation
Funds Awarded: £99,500
Location: University of Dundee, Scotland
Project Title: Analysis of a novel p53 induced gene "Scotin" that promotes apoptosis
Funds Awarded: £128,871
Location: University College London, England
Project Title: Antagonistic effects of the p53 and Brn-3a transcription factors on Bcl-2 proto-oncogene expression and apoptosis in neuroblastomas
Funds Awarded: £117,521
Location: University of Aberdeen, Scotland
Project Title: Control of life and death in human cancer cells by tumour necrosis factor receptor subtypes
Funds Awarded: £51,505
Location: University College London, England
Project Title: Synthetic and spectroscopic studies of 5-aminolaevulinic acid derivatives for photodynamic therapy
Funds Awarded: £71,990
Location: University of Birmingham, England
Project Title: IGF2 Imprinting and human cancer: Studies of Beckwith-Wiedemann Syndrome and Colorectal Cancer
Funds Awarded: £116,097
Location: University of Dublin, Republic of Ireland
Project Title: Mechanism of interaction between GSTP1 and JNK; Mechanism of interaction of glutathione S-transferase P1-1 (GSTP1) with jun N-terminal kinase (JNK): Implications for aberrant regulation of apoptosis
Funds Awarded: £55,950
Location: University of Essen Medical School, Germany
Project Title: Loss and gain of function at the Evi-5/Gfi-1 locus on chromosome 1p22: significance for tumour formation
Funds Awarded: £51,000
Location: European Institute of Oncology
Project Title: Structural Characterisation of the SCF Ubiquitin-Ligase Complex
Funds Awarded: £71,460
Location: The Institute of Cancer Research
Project Title: Novel Inhibitors of Telomeres and the Telomerase Enzyme
Funds Awarded: £125,110
Location: Cyprus Institute of Neurology & Genetics, Cyprus
Project Title: Repair of p16 mutations in human tumour cell lines
Funds Awarded: £98,515
Location: University of Cambridge, England
Project Title: Further analysis of the nuclear translocation of human cyclin B1-cdc2 at mitosis
Funds Awarded: £98,972
Location: K917/National Jewish Medical and Research Center
Project Title: The role of the SHP2-binding protein, Gab2, in T cell signaling pathways
Funds Awarded: £135,936
Location: University of Cambridge, England
Project Title: The identification of cellular markers of progression in vulval intraepithelial neoplasia
Funds Awarded: £90,453
Location: International Agency for Research on Cancer
Project Title: Mapping of cancer susceptibility genes and their modifiers by genomic mismatch scanning (GMS).
Funds Awarded: £129,514
Location: University of Salford, England
Project Title: Synthesis of Novel Heterocycles Targeted at Tumour Vasculature.
Funds Awarded: £60,390
Location: Garvan Institute of Medical Research
Project Title: Characterisation of EDD, a potential human tumour suppressor gene
Funds Awarded: £87,221
Location: The University of Bradford, England
Project Title: Synthesis and Evaluation of Pyrimidine-N-oxides as Novel Bioreductive Prodrugs
Funds Awarded: £52,840
Location: International Agency for Research on Cancer
Project Title: Genetic and functional studies of the role of the SH2D1A and SLAM genes in X-linked lymphoproliferative disease and in other Epstein-Barr virus-associated diseases
Funds Awarded: £100,650
