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Professor Alan Clarke |
Area of Expertise: DNA and the causes of cancer malignancy
Early genetic events in neoplasia. Genome surveillance, p53, induction of apoptosis. Whole organ/animal view of events Tg animals, APC/WT1/Msh2/Pms2/Mbd4
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Professor Bruno Amati |
Area of Expertise: Oncogenes, Chromatin and Cell Cycle Control.
Myc, Tip 60. Epigenetics, histone acetylation. High through-put genome analysis
Visit Official Website |
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Professor Manuela Baccarini |
Area of Expertise: The Baccarini group has a longstanding interest in the regulation and in the physiological role of the MAPK pathway, and specifically of Raf kinases. Recently, the group has performed the conditional and conventional knockout of the Raf kinases and of their effector MEK-1. The knockout of Raf-1 has revealed an unexpected, essential anti-apoptotic role for this enzyme independent of the activation of the MEK/ERK cascade. The current focus of the lab is the analysis of the function of Raf-1, B-Raf and MEK-1 by conditional gene ablation in the mouse.
Visit Official Website |
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Dr Axel Behrens |
Area of Expertise: To understand the molecular mechanism of cancer development and neurodegeneration in order to identify targets for therapeutic intervention. |
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Professor Antony Carr |
Area of Expertise: We have, along with others developed S. pombe as a model system for studying DNA damage responses. Our current work focuses on the links between checkpoint, cell cycle, replication and recombination repair pathways. |
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Dr Simon Cook |
Area of Expertise: MAP kinase signalling pathways and life or death decisions Visit Official Website
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Professor Ivan Dikic |
Area of Expertise: Endocytosis, growth factor receptors, ubiquitination, lipid rafts, RTKs, EGFR, Src, PI3, CIN/CMS, Cbl Visit Official Website |
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Professor Jeff Evans |
Area of Expertise: Translational research. Telmerase. Molecular therapeutics/ pharmacology. Gene Therapy
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Dr Jos Jonkers |
Area of Expertise: Mouse models for breast cancer. |
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Professor Peter Lichter |
Area of Expertise: Molecular cytogenetics (FISH, CGH). Microarray analysis of tumours
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Area of Expertise: Actin in cell migration, invasion and matastasis. Visit Official Website
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Professor John Masters |
Area of Expertise: Prostate cancer |
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Professor Maria Masucci |
Area of Expertise: Cancer Immunology. Immune response to tumour viruses. Ubiquitin system
Visit Official Website |
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Professor James Neil |
Area of Expertise: Cancer Virology. Retroviruses. Leukaemogenesis. Vaccines/immune response. Gene Therapy
Visit Official Website |
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Professor Neil Perkins |
Area of Expertise: NF kappa B, AFR, p53 pathways
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Dr Jonathan Pines |
Area of Expertise: Cell Cycle, Mitosis. FRAP/FRET
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Professor Alan Rickinson |
Area of Expertise: Tumour immunology & tumour virology
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Professor Michael Seckl |
Area of Expertise: Cancer cell biology, molecular oncology, lung cancer, trophoblastic research. |
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Professor Ian Stratford |
Area of Expertise: Cancer Biology. Angiogenesis. Hypoxia. Radiobiology. Gene Therapy. Drug Development |
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Dr Michael Threadgill |
Area of Expertise: Medicinal Chemistry, Drug Development
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Professor Andreas Trumpp |
Area of Expertise: Cancer genes and stem cells |
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Professor Ellen Van Obberghen-Schilling |
Area of Expertise: Angiogenesis, MAPK pathway, Rho, endothelial cells
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Professor Ulla Vogel |
Area of Expertise: Genetic epidemiology of cancer, DNA repair genes and cancer. Diet and cancer
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Professor Harry Vrieling |
Area of Expertise: DNA repair and recombination. HPRT gene (Lesch Nyhan syndrome).UV-induced DNA damage
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Professor John Wyke |
AICR Board of Directors (ex-officio)
Area of Expertise: cell and molecular biology of neoplastic transformation, viral oncoproteins, SRC family kinases
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Dr Mark Matfield |
AICR's Scientific Coordinator (ex-officio) - provides a link between AICR and the SAC for the Grants Process. |
SAC Biographies |
