Projects funded from October 2004
Location: Cleveland Clinic Foundation, United States of America
Project Title: Investigation of the Prognostic Value and role of fascin in colon carcinoma
Funds Awarded: £130,346
Location: University of Dundee, Scotland
Project Title: Regulation and function of the LKB1 tumour suppressor
Funds Awarded: £125,993
Location: Imperial College of Science Technology & Medicine, England
Project Title: Modulation of Estrogen Receptor activity by protein kinase A: Mechanisms and significance for breast cancer
Funds Awarded: £84,820
Location: European Institute of Oncology, Italy
Project Title: Functional interactions between Myc and Wnt signalling in transcriptional regulation and cancer
Funds Awarded: £86,508
Location: University of Exeter, England
Project Title: Role of Mcm 10 in the initiation of DNA replication
Funds Awarded: £116,900
Location: San Raffele Research Institute, Italy
Project Title: The role of HMGB1 in tumour growth
Funds Awarded: £95,163
Location: University of Southampton, England
Project Title: Regulation of Hdm2 oncoprotein expression by mitogenic signalling pathways
Funds Awarded: £129,651
Location: University College London, England
Project Title: Coordination between junction disassembly and cell motility in human keratinocytes
Funds Awarded: £83,700
Location: University of Glasgow, Scotland
Project Title: critical molecular pathways in cell transformation and immune evasion by E6 and E7 proteins of Group B1 cutaneous human papillomaviruses associated with non-melonoma skin cancer
Funds Awarded: £245,970
Location: Fondazione Italiana per la Ricerca sul Cancro, Italy
Project Title: NCAM-mediated modulation of B, integrin in tumor progression
Funds Awarded: £87,501
Location: Cancer Research UK Paterson Institute, England
Project Title: Lipidomic Analysis of Metastatic Prostate Cancer
Funds Awarded: £114,571
Location: University of Leeds, England
Project Title: Transgenic mouse models for studying activation of autocrine growth factor genes by the BCR-ABL oncogene
Funds Awarded: £149,238
Location: University of Southampton, England
Project Title: Mechanism of CD20 included apoptosis
Funds Awarded: £133,020
Location: University of Sussex, England
Project Title: Roles of 53BP1 in DNA double-strand break repair
Funds Awarded: £134,627
Location: Institut Curie, France
Project Title: Study of the molecular mechanisms involved in the transforming properties of the FLI-1 oncoprotein
Funds Awarded: £139,500
Location: Beatson Institute for Cancer Research, Scotland
Project Title: Identifying mitochondria-generated signals that trigger tumourigenesis: a link between the inhibition of the tricarboxylic acid cycle and cancer
Funds Awarded: £127,976
Location: University Amedeo Avogadro of Piemonte Orientale, Italy
Project Title: The role of a-Dicyglycerol kinase in HGF-adhesion-and-v-Src induced migratory and invasive signalling
Funds Awarded: £22,565
Location: Medizinische Hochschule Hannover, Germany
Project Title: idenification and characterisation of CD4+ T cell in renal cell carcinoma
Funds Awarded: £158,682
Location: University of Bristol, England
Project Title: Cyclooxygenase 2 and prostaglandin E2 as targets for fenretinide in oral cancer prevention
Funds Awarded: £122,475
Location: University of Manchester, England
Project Title: An investigation into the oncogenic properties of the PDZ protein Tip-1
Funds Awarded: £123,119
Location: Medical Research Council, England
Project Title: The WT1 - b-catenin connection in wilms' tumors
Funds Awarded: £153,339
Location: Erasmus University Rotterdam, The Netherlands
Project Title: Tumour suppressor function of the signalling molecules Btk and SLP-65 in pre-B cells
Funds Awarded: £153,104
Location: The University of Durham, England
Project Title: The role of lamin A in gene regulation in adrenal cortex carcinoma cell lines
Funds Awarded: £189,181
Location: Imperial College School of Medicine at Hammersmith Campus, England
Project Title: Role & regulation of FOXO transcription factors in hormone dependent & antiestrogen resistant breast cancer
Funds Awarded: £135,765
Location: University of Dundee, Scotland
Project Title: The nuclear localisation of the PTEN tumour suppressor: cellular function and regulation
Funds Awarded: £72,888
Location: University of Sheffield, England
Project Title: Characterization of a fragment of human fibrinogen, fibrinogen E-Fragment with selective cytotoxicity for activated endothelial cells
Funds Awarded: £129,625
Location: University of Durham, England
Project Title: Role of syndecan-1 in epidermal cell migration and proliferation
Funds Awarded: £123,552
Location: University of the Basque Country School of Medicine, Spain
Project Title: Transcriptional regulation of DDR2 receptor in the tumor-associated myofibroblasts in primary & metastatic cancer
Funds Awarded: £40,100
Location: St George's Hospital Medical School, England
Project Title: Protecting heamopoietic stem cells and blocking leukeamic cell growth using a cell permeable HOX/PBX interfering peptides
Funds Awarded: £95,514
Location: University of Birmingham, England
Project Title: Proteomic analysis of the contribution of the Epstein-Barr virus to the pathogenesis of Hodgkin's lymphoma
Funds Awarded: £124,300
Location: King's College London, England
Project Title: Structure-function studies of the p53 homologous protein p73
Funds Awarded: £83,700
Location: University of Dundee, Scotland
Project Title: PPARo as a drug target in prostate cancer
Funds Awarded: £114,983
Location: King's College Hospital, England
Project Title: Rapid Early Detection of Residual Cancer
Funds Awarded: £144,755
Location: University of Birmingham, England
Project Title: Epstein-Barr virus and carcinogenesis: a novel in vitro system to study the mechanism of viral entry into human epithelial cells
Funds Awarded: £126,628
Location: Leiden University Medical Centre, The Netherlands
Project Title: Elucidation of the molecular and cellular mechanisms underlying desmoid disease (aggressive fibromatosis)
Funds Awarded: £144,713
Location: Newcastle University, England
Project Title: Regulation of HDAC1; a component of the androgen receptor transcriptosome and potential therapeutic target in prostate cancer
Funds Awarded: £129,660
Location: University of London, England
Project Title: Targeting the p53/MDM2 interaction. Analogues of chlorofusin as potential antitumour agents
Funds Awarded: £124,467
Location: University of Aberdeen, Scotland
Project Title: Mechanisms responsible for changes in FDG uptake by tumours responding to conventional and to novel therapy
Funds Awarded: £66,695
Location: Free University of Brussels, Belgium
Project Title: Role of osteopontin and its receptors in the tumor-host interactions in multiple myeloma
Funds Awarded: £65,400
Location: Babraham Institute, England
Project Title: Mechanisms of heterochromatin remodelling for DNA replication
Funds Awarded: £125,762
Location: University of Cambridge, England
Project Title: The role of Stat3 isoforms in regulating apoptosis and tumourigenesis
Funds Awarded: £156,295
Location: University of Oxford, England
Project Title: Dissecting the growth regulatory functions of the ski/sno oncogene family in drosophila
Funds Awarded: £125,808
Location: Erasmus MC, The Netherlands
Project Title: The human genome maintenance complex Rad50/Mre11/Nbs1: Analysis of structural requirements for oligomerization and DNA tethering activity
Funds Awarded: £151,779
Location: Marie Curie Research Institute, France
Project Title: Mechanisms of the APC/C dependent ubiquitylation And proteolsis
Funds Awarded: £129,314
