Projects funded from April 2004
Location: University of Southampton, England
Project Title: Regulation of CD30 signalling by receptor shedding
Funds Awarded: £133,684
Location: Mario Negri Institute, Italy
Project Title: PDZ proteins and tetraspanins in the crosstalk between JAM-1 and extracelular matrix receptors. Functional role in endothelial cell migration
Funds Awarded: £64,500
Location: Fondazione Italiana per la Ricerca sul Cancro, Italy
Project Title: Genetic dissection of the activity of the urokinase receptor in cancer
Funds Awarded: £139,329
Location: Cancer Research UK, England
Project Title: Study the interactions between normal and leukaemic cells
Funds Awarded: £170,647
Location: University of Cambridge, England
Project Title: Dog odour discrimination and human health
Funds Awarded: £48,210
Location: Beatson Institute for Cancer Research, Scotland
Project Title: Role of Chk1 and Chk2 as effectors of mismatch repair-dependent G2/M arrest and apoptosis
Funds Awarded: £114,591
Location: Fondazione Italiana per la Ricerca sul Cancro (IFOM), Italy
Project Title: Whole genome RNAi screen to uncover genes involved in Rho GTPase function using C.elegans as a model
Funds Awarded: £22,759
Location: University of Leuven, Belgium
Project Title: Structure-function analysis of the amino-terminal domain of the androgen receptor and its co-activators
Funds Awarded: £102,204
Location: Uppsala University, Sweden
Project Title: Molecular mechanisms regulating endothelial cell sprouting
Funds Awarded: £110,000
Location: St George's Hospital Medical School, England
Project Title: Signalling mechanisms in translational control by tumour necrosis factor and TRAIL
Funds Awarded: £157,279
Location: University of Dundee, Scotland
Project Title: The role of p53-family members, p63 and p73 in survival and differentiation of haemopoietic cells
Funds Awarded: £131,980
Location: Laboratoire Nazionale CIB, Italy
Project Title: Dissecting the role of the prolyl-isomerase Pin1 in regulating the activity of wild-type p53 and tumour derived mutants
Funds Awarded: £78,240
Location: Erasmus MC, Josephine Nefkens Institute, The Netherlands
Project Title: Functional screen for endocrine resistance of breast cancer
Funds Awarded: £135,070
Location: University of Marburg, Germany
Project Title: Systematic identification of critical Myc target genes using bar code cloning techniques
Funds Awarded: £133,586
Location: University of Southampton, England
Project Title: The identification of cryptic tumour antigens recognised by cytotoxic T cell generated in the absence of CD25 +CD4+ regulatory T cells
Funds Awarded: £87,133
Location: Keele University, England
Project Title: Functional analysis of polymorphism in GSTP1
Funds Awarded: £116,769
Location: Biomedical Sciences Research Centre 'Al. Fleming', Greece
Project Title: The role of bone morphogenetic proteins in the homeostasis of lymphoid tissues - implications for lymphomas
Funds Awarded: £98,684
Location: The Hebrew University, Israel
Project Title: Regulation of the p53/Mdm2 interplay by PML
Funds Awarded: £53,148
Location: St Andrews University, Scotland
Project Title: Role of SUMO modification in the cellular response to ionising radiation
Funds Awarded: £126,814
Location: University of Dundee, Scotland
Project Title: Mechanism by which cancer chemoprevention blocking agents stabilize the Nrf2 transcription factor and inhibit its Keap1-mediated degradation
Funds Awarded: £125,992
Location: University of Aberdeen, Scotland
Project Title: Molecular mechanisms of tissue-specific Wnt signalling in embryonic development and cancer
Funds Awarded: £146,147
Location: University of Dundee, Scotland
Project Title: Function of a novel anti-apoptotic stress protein expressed in barretts oeosophagus
Funds Awarded: £120,473
Location: National Health Institute 'Dr Ricardo Jorge', Portugal
Project Title: Alternative splicing confers novel signalling properties to Rac1, a role in colorectal tumour progression
Funds Awarded: £23,000
Location: Queen Mary & Westfield College, University of London, England
Project Title: Investigating the Wnt16 signalling pathway in BCC development
Funds Awarded: £129,634
Location: University of Torino, Italy
Project Title: Role of the Rab5-GAP, RN-tre in signalling and mitosis
Funds Awarded: £47,600
Location: Harvard Medical School, United States of America
Project Title: Analysis of p63 function in mammary epithelial biology and oncogenesis
Funds Awarded: £143,797
Location: University of Birmingham, England
Project Title: MIM, a metastasis suppressor that regulates the actin cytoskeleton
Funds Awarded: £109,500
Location: Free University of Brussels (ULB), Belgium
Project Title: Mdm4 is a putative oncoprotein that negatively regulates p53 activity in vivo
Funds Awarded: £138,441
Location: Catholic University of Leuven, Belgium
Project Title: MALTI-induced NF-Kb signalling in MALT lymphoma with MALT1 overexpression or AP12-MLT1 fusion
Funds Awarded: £107,587
Location: European Molecular Biology Laboratory, Italy
Project Title: The role of C/EBPx in acute myeloid leukemia: a genetic approach to proteomics
Funds Awarded: £167,685
Location: University of Oxford, England
Project Title: The role of the human INT6 gene in tumourigenesis
Funds Awarded: £120,594
Location: University of Helsinki, Finland
Project Title: Androgen receptor-dependent transcriptional regulation in prostate cells: coregulator dynamics and the role of ubiquitin and SUMO modifications
Funds Awarded: £129,108
Location: Medical Research Institute, England
Project Title: Establishing a forward genetic system for defining defective DNA repair in Fanconi anemia
Funds Awarded: £97,241
Location: Peter MacCallum Cancer Institute, Australia
Project Title: The double-edged sword of NKT cells in tumour immunity
Funds Awarded: £140,241
Location: CNRS EP560, France
Project Title: Analysis of the role of VE-statin in vitro and in vivo
Funds Awarded: £45,000
Location: Mario Negri Institute, Italy
Project Title: Identification and properties of tumor associated dendritic cell subsets
Funds Awarded: £64,800
Location: University of Maastricht, The Netherlands
Project Title: Identification of genes involved in endocrine pancreatic tumor development and progression
Funds Awarded: £119,853
Location: University of Bath, England
Project Title: Quinoline-8-carboxamide N-oxides as (bio)reductively-activated prodrugs of radiosensitisers and chemosensitisers
Funds Awarded: £77,705
Location: The University of Hong Kong, China
Project Title: Significance of MAD2 expression to chromosomal instability in prostate cancer
Funds Awarded: £127,407
Location: Cardiff University, Wales
Project Title: Checkpoint kinase 2: structure activity determination and novel ligand design
Funds Awarded: £30,409
