Projects funded from 1 April 2003
Location: Liverpool John Moores University, England
Project Title: Exploitation of deregulated tumour glucose transport and metabolism for novel anticancer strategies
Funds Awarded: £127,750
Location: Instituto de Investigaciones Biomedicas, Spain
Project Title: Regulation of proto-oncogenic Cot kinase activity by extracellular signals. Implication of Cot kinase activity in apoptosis
Funds Awarded: £72,090
Location: Imperial College of Science Technology & Medicine, England
Project Title: "Phosphoinositide 3-kinases in the control of proliferation and survival of small cell lung cancer"
Funds Awarded: £138,343
Location: Cancer Research UK, England
Project Title: Regulation of hif-1activity and function
Funds Awarded: £131,378
Location: Justus-Liebig-University, Germany
Project Title: Novel strategies for androgen receptor inactivation in prostate cancer
Funds Awarded: £151,230
Location: University of Oxford, England
Project Title: Gene expression profiling in polycythaemia rubra vera using cDNA microarray technology
Funds Awarded: £130,639
Location: University of Sheffield, England
Project Title: Photodynamic therapy-induced tumour imunity: A role for heat shock proteins?
Funds Awarded: £140,935
Location: St George's Hospital Medical School, England
Project Title: Analysis of the human TTC4 protein, its role in the control of DNA replication proteins and its relationship to the development of malignant melanoma
Funds Awarded: £153,870
Location: Garvan Institute of Medical Research, Australia
Project Title: The role of the Gab2 docking protein in human breast cancer
Funds Awarded: £106,705
Location: INSERM U 509, Institut Curie, France
Project Title: Characterisation of EWS and EWS-FLI-I associated proteins. Role of these interactions in the oncogenesis of Ewing tumours
Funds Awarded: £81,012
Location: University of Manchester, England
Project Title: Understanding the activation of pro-apoptotic proteins bid and bax in order to develop novel therapeutic approaches that lower the threshold for drug-induced apoptosis in tumour cells
Funds Awarded: £48,886
Location: University of Dundee, Scotland
Project Title: Is the tumour specific expression of cytochrome P450 CYP1B1 caused by post-transcriptional mechanisms?
Funds Awarded: £66,750
Location: Institut Curie, France
Project Title: Study of the molecular mechanisms involved in TEL-JAK2 induced leukaemia
Funds Awarded: £145,250
Location: University of Glasgow & The Beatson Institute for Cancer Research, Scotland
Project Title: Genetic analysis of the role and mechanism of Chk1 regulation in the replication and DNA damage checkpoints and in determining tumour cell survival in response to anti-cancer drugs
Funds Awarded: £133,494
Location: Forschungszentrum Karlsruhe, Germany
Project Title: Control of histone deacetylase-2 (HDAC-2) by the APC tumour suppressor and its implications in colon carcinogenesis
Funds Awarded: £147,980
Location: King's College London, England
Project Title: Harnessing the allergic reaction to combat ovarian cancer
Funds Awarded: £170,571
Location: University of Bristol, England
Project Title: Bag-1 proteins in oral carcinogenesis: evaluation of the implications for chemoprevention and therapy
Funds Awarded: £129,854
Location: University of Dundee, Scotland
Project Title: Contribution of Nrf1 isoforms to regulation of the ARE-gene battery by cancer chemopreventive blocking agents
Funds Awarded: £123,303
Location: Danish Cancer Society, Denmark
Project Title: Lysosomal Hsp70 as a target for cancer therapy
Funds Awarded: £158,109
Location: Cancer Research UK, England
Project Title: Using inducible clonal targeting to analyse the function of Notch in normal and premalignant intestinal stem cells
Funds Awarded: £148,556
Location: The Hebrew University-Hadassah Medical School, Israel
Project Title: SNF5 conditional mutation, a mouse model for childhood malignant rhabdoid tumour
Funds Awarded: £140,170
Location: Brunel University, England
Project Title: Molecular basis of genetic instability in tetranucleotide repeats in human cancers
Funds Awarded: £35,239
Location: The Hong Kong University of Science & Technology, Hong Kong
Project Title: Molecular characterisation of the EWS oncogene and evaluation of potential peptide inhibitors
Funds Awarded: £85,892
Location: University Medical Centre Utrecht, The Netherlands
Project Title: Antibody dependent tumour lysis by FcxRI (CD89) is regulated by Mac-1 (CD11b/CD18): dissection of signalling pathways
Funds Awarded: £126,450
Location: Consejo Superior de Investigacions Cientificas, Spain
Project Title: Molecular mechanisms regulating the sensitivity of breast tumour cells to TRAIL-induced apoptosis
Funds Awarded: £89,270
Location: University of Aberdeen, Scotland
Project Title: Structural and functional analysis of the androgen receptor amino terminal domain: role of protein-protein interactions
Funds Awarded: £61,050
Location: University of Dundee, Scotland
Project Title: Phosphorylation of the Hdm2 protein at the critical serine 260 and 262 residues: signalling mechanism(s) and role in regulating the p53 response
Funds Awarded: £110,957
Location: Garvan Institute of Medical Research, Australia
Project Title: Identification and functional analysis of oestrogen-induced c-Myc target genes in breast cancer cells
Funds Awarded: £117,573
Location: University of Dundee, Scotland
Project Title: How does the interplay between intra-and intermolecular interactions of the Adenomatous Polyposis Coli protein regulate its multiple functions in cancer?
Funds Awarded: £127,729
Location: University of Crete Medical School, Greece
Project Title: Study of the in vivo effect of an anti-TNFx monoclonal antibody (cA2) on bone marrow stem/progenitor cell reserve and function and on bone marrow stromal cell function in patients with myelodysplastic syndromes.
Funds Awarded: £39,000
Location: Imperial Cancer Research Fund, England
Project Title: Role of BAF57 and UPOC cofactor proteins in oestrogen action
Funds Awarded: £141,217
Location: Copenhagen University Hospital, Denmark
Project Title: C/EBPalpha in myeloid leukaemia
Funds Awarded: £161,745
Location: University of Manchester, England
Project Title: Identification of target genes for the TCF ETS-domain transcription factors
Funds Awarded: £140,297
Location: IGBMC, France
Project Title: The role of human TAFII68, EWS and TLS/FUS and their oncogenic derivatives in regulating transcription by RNA polymerase II
Funds Awarded: £115,251
Location: University of Crete, Greece
Project Title: Immunomodulation by tumour-derived neuropeptides
Funds Awarded: £66,101
Location: Erasmus University Rotterdam, The Netherlands
Project Title: Biological impact of cyclobutane pyrimidine dimers and 6/4 photoproducts induced by ultraviolet light
Funds Awarded: £129,266
Location: Cancer Research UK, England
Project Title: The role of the chemokine CXCL12 and its receptor CXCR4 in human ovarian cancer
Funds Awarded: £168,432
Location: The Austin Research Institute, Australia
Project Title: Growth inhibitory antibodies in colon cancer
Funds Awarded: £128,247
