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Position
AICR Fellow / Team Leader, Haemato-Oncology Section
Location
The Institute of Cancer Research, United Kingdom (England)
Funds Awarded
£926,718.00
Period of Award
1st October 2003 - 30th September 2011
Project Title
Mechanisms of leukaemogenesis by MLL chimaeric fusion proteins.
Project Summary
Many types of cancer are caused by damage to genes that control the way cells grow and multiply. Dr So is investigating a gene called MLL, which has been found to be damaged in many types of leukaemia. It is most frequent in aggressive leukaemias that do not respond well to treatment. Currently, we do not understand how the altered MLL gene activates the genes which make the leukaemia cells multiply rapidly and out of control. Dr So will be investigating the MLL gene and how it makes blood cells become leukaemic.
Publications
Kwok C, Zeisig BB, Dong S, So CWE (2006), Forced homo-oligomerization of RAR alpha leads to transformation of primary hematopoietic cells. CANCER CELL, 9 (2). pp. 95-108. ISSN 1535-6108
Zeisig, B. B., Kwok, C., Zelent, A., Shankaranarayanan, P., Gronemeyer, H., Dong, S., So, C. W. E. (2007), Recruitment of RXR by homotetrameric RAR alpha fusion proteins is essential for transformation. CANCER CELL, 12 (1). pp. 36-51. ISSN 1535-6108
Cheung, N., Chan, L. C., Thompson, A., Cleary, M. L., So, C. W. E. (2007), Protein arginine-methyltransferase-dependent oncogenesis. NATURE CELL BIOLOGY, 9 (10). pp. 1208-1215. ISSN 1465-7392
Kwok C, Zeisig BB, Dong S, So CWE (2006), Forced homo-oligomerization of RAR alpha leads to transformation of primary hematopoietic cells. CANCER CELL, 9 (2). pp. 95-108. ISSN 1535-6108